Gene therapy offers hope for patients with ischemic limbs facing amputation

Author: Zhang Jun, Chief Physician of the Vascular Surgery Department at the National Emergency Medical Research Center, Emergency General Hospital. Reviewer: Gu Yongquan, Chief Physician of the Vascular Surgery Department at Xuanwu Hospital, Capital Medical University, and Chief Expert in Vascular Surgery at the National Emergency Medicine Research Center. Title: Gene therapy offers hope for patients with ischemic limbs facing amputation Introduction: Gene therapy and Sedomin injection offer new hope for lower limb ischemia patients ineligible for surgery, improving treatment options. Keywords: ['treatment', 'medical innovation']

"Doctor, will I be able to keep my leg?" This is the most pressing concern for many patients with severe lower limb ischemia. When the vascular condition is too poor for conventional bypass or interventional surgery, patients may feel that treatment is hopeless. However, gene therapy—a new technology—provides hope for limb preservation for those considered "inoperable." 1. "Inoperable" is not the end of the road! "Unable to perform surgery" does not mean there is no hope; it simply indicates that conventional surgical methods are not feasible, necessitating alternative treatment explorations. This situation often arises in the following instances: New Treatment Methods: The transition from "external repair" to "self-repair" can be understood as follows: Core Weapon: The "Life Code" of HGF Gene Therapy Among the substances promoting blood vessel growth, "Hepatocyte Growth Factor" (HGF) stands out for its significant effects. It not only stimulates angiogenesis but also reduces inflammation and tissue edema, providing a favorable environment for new blood vessels. The Sedomin injection developed in our country is based on this principle: IV. Real Case: Exciting Results from Clinical Trials An important clinical study (HOPE-CLTI-2) has achieved promising outcomes: Does this relate to me? Am I (or my family) suitable for it? Potential suitable audience: ⚠ Important reminder: Gene therapy is a powerful new method in the "comprehensive treatment plan" for preserving limbs, but it is not a "cure-all." Successful leg preservation also requires cooperation with the following basic treatments: Dear friend, if you or your family are facing a situation where there seems to be "no way out," feeling helpless and confused, please do not lose hope. Every advancement in medicine transforms the "impossible" into the "possible." Gene therapy represents a new stage in the treatment of lower limb ischemia, entering the realm of "angiogenesis." It no longer solely depends on devices to clear blockages but seeks to awaken your body’s innate healing abilities, enabling your tissues to grow new lifelines independently. This reflects a hopeful medical philosophy: to trust and activate the power of life itself. Good news: the application for the marketing authorization of Sedomin Injection has been officially submitted. This innovative therapy is anticipated to assist many patients soon! Please ensure thorough communication with your vascular surgeon about your specific situation and jointly assess if this new option is right for you. The best plan will always be the personalized strategy specifically designed by your doctor. Preserving limbs and regaining the ability to stand and walk—this once-distant dream is increasingly becoming a reality with the support of new technologies like gene therapy. Please believe that every life that refuses to give up is worth fiercely protecting. The vascular surgery team will safeguard your vascular health and accompany your hopes.