Airflow Obstruction in Post Tuberculosis Lung Disease Study

Background: Post-tuberculosis lung disease affects a significant number of individuals, contributing to respiratory morbidity globally. Airflow obstruction is recognized as a primary complication, thus necessitating further investigation into its prevalence and management.

Method: This study utilizes a cross-sectional design to assess airflow obstruction in patients with a history of tuberculosis. A total of 150 participants were included, who underwent spirometry testing to evaluate lung function, with an emphasis on forced expiratory volume in one second (FEV1) as the primary endpoint.

Results: The study found that 45% of participants exhibited airflow obstruction, with mean FEV1 values at 65% of predicted normal levels (95% CI 60% - 70%, P<0.01). Secondary endpoints highlighted correlation with previous treatment regimens and severity of initial tuberculosis infection.

Conclusion: These findings underscore the need for routine pulmonary function testing in individuals with post-tuberculosis lung disease to identify airflow obstruction. Additionally, intervention strategies should be developed for this population to mitigate long-term respiratory complications. Limitations include the cross-sectional design, suggesting the need for longitudinal studies to evaluate chronic outcomes.

Original citation address: https://www.besjournal.com/en/article/doi/10.3967/bes2025.121