Thyroid Hormone Sensitivity Linked to Fatty Liver Disease

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) affects approximately 25% of the global population, leading to significant morbidity and mortality. Understanding the relationship between thyroid hormone sensitivity and MAFLD is essential, given the potential impact on metabolic health management.

Method: This study involved a cross-sectional analysis of 1,200 adults with a range of thyroid function statuses. Participants were assessed for MAFLD diagnosis using liver imaging techniques and thyroid hormone sensitivity was evaluated through serum hormone measurements. Statistical analysis included logistic regression to explore associations between thyroid sensitivity and MAFLD.

Results: Participants with lower thyroid hormone sensitivity had a 32% increased prevalence of MAFLD compared to those with normal sensitivity (prevalence 40% vs 30%, P<0.01). Additionally, each 1-unit decrease in thyroid sensitivity score was associated with a 21% increased risk of MAFLD (95% CI 12%-30%). No significant differences in safety events were reported.

Conclusion: The findings suggest that reduced thyroid hormone sensitivity is associated with an increased risk of MAFLD, supporting the need for screening and management of thyroid function in patients with metabolic disorders. However, as this study is cross-sectional, causality cannot be established, and further longitudinal studies are required to validate the findings.

Original citation address: https://www.besjournal.com/en/article/doi/10.3967/bes2026.005